
MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring mitochondrial-derived peptide (MDP) consisting of 16 amino acids. Unlike nuclear-encoded peptides, MOTS-c is encoded within the mitochondrial genome, functioning as a "mitokine" that facilitates communication between mitochondria and the nucleus. In research settings, it is primarily studied for its role in regulating metabolic homeostasis, enhancing mitochondrial function, and its potential influence on longevity and physical performance models.